Tuesday, February 12

Journal #8: Royal Families and Founder's Effect



I remembered a while back, when my socials teacher was mentioning the commonality of royal families’ inbreeding, in order to “keep the royal blood” within. One of the said families developed a hereditary genetic disorder called haemophilia, in which the affected individual’s body is impaired in the way that their blood does not clog. With a bit of research, haemophilia proves congruous to my hypothesis, considering the inbred lineage: it is a recessive trait (although I am oversimplifying here). 

King Charles II of Spain, who suffered from many genetic disorders
                                                                                          
Most of the descendants of these inbreeding families carried many rare genetic disorders, one of the famous examples being Charles II of Spain, who suffered from numerous (manymanymang) disabilities, mental, physical and emotional. These inbred-born birth defects do embody the concept of founder effect. Reproductively isolated and with a controlled, along with very small, gene flow, each of those royal families have a relatively high frequency of inherited disorders. Considering the genetic diversity, or in other words, not procreating with someone very genetically similar to themselves, is the key to life: as it prevents the expression of deleterious, recessive genes (aka bad, harmful traits). Moreover, traits like Hapsburg jaw and hemophilia are quite prevalent in participants of inbred lineage, but do not represent the majority population (I have never met one whose tongue is so engorged they drool)—indicating a bit of reference to bottleneck effect, or the population not representing the allele frequencies of the initial one, as well. The range of recessive genes is pretty remarkable, despite the tragedy of it all (bleeding to death from a paper cut?). However, I do have one question: do they eventually turn into a new species, if given enough time for their reproductive isolation? Or just simply meet their recessive deaths, leaving no descendants behind?

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